A scientific journey that began in Bad Camberg, a small town in Germany, has reached a major milestone at the Institute of Science and Technology Austria with the Professorship of Sandra Siegert coming into effect this month. Professor Sandra Siegert investigates the role of microglia in the
Venturino et al. show that repeated ketamine anesthesia results in perineuronal net loss, which promotes juvenile-like, ocular-dominance plasticity in adult mice. Microglia are key players in the PNN disassembly, in which 60-Hz light entrainment reproduces that phenotype, providing an alternative, non-invasive strategy to remodel PNNs.