Advancing mental health care through innovative new solutions.

Syntropic is a clinical stage medical device company developing new technologies that enhance the brain’s neuroplasticity, allowing for the treatment of psychiatric disorders and the improvement of cognition.

Syntropic’s mission is to advance mental health care through the development of innovative technologies that target underlying causes of brain disorders.
Flythrough

Syntropic offers a non-invasive and non-pharmaceutical treatment for mental health disorders. Through light stimulation, neural remodeling is activated by instructing the immune cells of the brain to support in healing and recovery.

Psychiatric disorders are a severe burden on society

Psychiatric disorders have become a severe burden on society. In Europe alone, an estimated 90M people are living with depression. For those people, the standard treatment options remain to be antidepressants which have now been in use for over 50 years. These options are no longer good enough, where over 50% of people will relapse and over 30% of patients will receive no benefit at all. However, new therapies are beginning to offer hope in the treatment of psychiatric disorders by focusing their efforts on modifying brain circuits, enabling the brain to form new connections and remodel itself.

Syntropic, providing a non-invasive alternative to drug therapy

​​While researching alternative therapies in this space, Syntropic's founders, in Venturino et al., 2021, made a breakthrough discovery whereby the immune cells of the brain could be instructed to alter structures in the brain associated with mental health conditions, all while using a non‑pharmaceutical and non‑invasive approach. This demonstration showed that Syntropic’s light based therapy reduces symptoms of depression and promotes cognitive function. This was achieved without any side effects, free of pharmaceuticals, and at low cost. Clinical development is now underway to deliver this technology to those who need it most.

Advancing mental health care for the unmet needs of patients

For patients who fail to receive the clinical benefit and/or struggle with the side‑effects of existing therapies, Syntropic offers a new and novel solution that has the potential to provide long‑lasting relief from psychiatric illness. With a focus on accessibility, affordability and patient‑usability, the solution offers significant benefits to both patients and healthcare systems. Syntropic aims to transform the landscape of mental health care through the advancement of health technology for the unmet needs of patients.

Non-Pharmaceutical

Non-Invasive

Targets Underlying Causes

Greater Accessibility

Cost-Effective

Side Effect Free

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Articles

Syntropic Medical secures early-stage funding from xista science ventures and aws

MedTech company secures 7-figure early-stage funding from xista science ventures and Austria Wirtschaftsservice, to develop light stimulation based treatment for mental health disorders such as Major Depressive Disorder.

Repeated Ketamine Anesthesia Restarts Plasticity in the Brain

Researchers have discovered two methods to restart plasticity in the brain, repeated ketamine anesthesia and non-invasive light flickering.

Repeated Ketamine Anesthesia Restarts Plasticity in the Brain

Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain

Venturino et al. show that repeated ketamine anesthesia results in perineuronal net loss, which promotes juvenile-like, ocular-dominance plasticity in adult mice. Microglia are key players in the PNN disassembly, in which 60-Hz light entrainment reproduces that phenotype, providing an alternative, non-invasive strategy to remodel PNNs.

Sandra Siegert Promoted to Professor

A scientific journey that began in Bad Camberg, a small town in Germany, has reached a major milestone at the Institute of Science and Technology Austria with the Professorship of Sandra Siegert coming into effect this month. Professor Sandra Siegert investigates the role of microglia in the

Innovation durch Kreativität: Wie Grundlagenforschung zum Gamechanger wird

Die Keynote von Martin Hetzer, Präsident Institute of Science and Technology Austria (ISTA), beim 4GAMECHANGERS Festival 2024.

Vienna-based Syntropic secures seven-figure funding to develop new treatment for Major Depressive Disorder | EU-Startups

Syntropic Medical, a medical device company spun out of the Institute of Science and Technology Austria (ISTA) by Mark Caffrey, Jack O’Keeffe, Dr.

Vienna-based Syntropic secures seven-figure funding to develop new treatment for Major Depressive Disorder | EU-Startups
Interested in joining our team? View our available jobs here.
Or become part of our journey to the new frontier of psychiatric care by reaching out to info@syntropicmedical.com and following us on social media.

Meet our team

Mark

Mark Caffrey

Co-Founder and CEO
alessandro

Alessandro Venturino

Co-Founder and Head of Research
Sandra

Sandra Siegert

Co-Founder
Jack

Jack O'Keeffe

Co-Founder and CTO
MT

Maria Teresa Ferretti

Clinical Development Lead
Amin Alam

Amin Alam

R&D Engineer
Frieda

Friederike Leesch

Biomedical Researcher
Francesca

Francesca Giovanetti

Founders Associate

Supporters

XSV

xista science ventures

AWS

Austria Wirtschaftsservice

ISTA

IST Austria

Disclaimer

  • Syntropic Medical GmbH, Plöcking 1, 3400 Klosterneuburg, Austria
  • info@syntropicmedical.com
  • Commercial register number: 613074f, AT U80004246
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